Postconditioning the human heart
نویسندگان
چکیده
Acute myocardial infarction is a frequent and disabling disease. Ischemic postconditioning, consisting of repeated brief cycles of ischemia-reperfusion performed immediately after reperfusion following a prolonged ischemic insult, dramatically reduces infarct size in experimental models. A recent clinical study demonstrated that repeated brief episodes of inflation-deflation of the angioplasty balloon performed immediately after re-opening of the culprit coronary artery reduced infarct size by 36% in patients with current acute myocardial infarction. This proof-of-concept study identified lethal reperfusion injury as a new target for future pharmacological treatments. Future therapeutic strategies for acute myocardial infarction should include mimetics of postconditioning. Heart Metab. 2007;37:19–22.
منابع مشابه
Effects of Postconditioning, Preconditioning and Perfusion of L-carnitine During Whole Period of Ischemia/ Reperfusion on Cardiac Hemodynamic Functions and Myocardial Infarction Size in Isolated Rat Heart
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Postconditioning the human heart.
BACKGROUND In animal models, brief periods of ischemia performed just at the time of reperfusion can reduce infarct size, a phenomenon called postconditioning. In this prospective, randomized, controlled, multicenter study, we investigated whether postconditioning may protect the human heart during coronary angioplasty for acute myocardial infarction. METHODS AND RESULTS Thirty patients, subm...
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